Advanced glycation end-products (AGEs) are harmful compounds that form when sugars react with proteins, lipids, or nucleic acids in the body. These compounds are associated with aging and various chronic diseases such as diabetes, cardiovascular disease, and Alzheimer's disease. AGEs can accumulate in tissues over time, leading to tissue damage, inflammation, and dysfunction. Factors that contribute to the formation of AGEs include a diet high in sugar and fat, oxidative stress, and chronic inflammation. AGEs can be measured in the body and are considered a biomarker of aging and disease.