A gut irritant refers to a substance or agent that can cause irritation or inflammation in the gastrointestinal tract. These irritants can lead to various symptoms such as abdominal pain, discomfort, bloating, diarrhea, or vomiting. Some common examples of gut irritants include certain medications (such as nonsteroidal anti-inflammatory drugs), spicy or highly seasoned foods, excessive alcohol consumption, caffeine, certain food additives, and certain gastrointestinal infections.