Advanced heart disease refers to severe, often chronic, conditions that affect the heart and its ability to function properly. This can include conditions such as heart failure, cardiomyopathy, coronary artery disease, and arrhythmias. Advanced heart disease may be caused by a variety of factors, including high blood pressure, high cholesterol, smoking, obesity, diabetes, and genetics. Symptoms can include shortness of breath, fatigue, chest pain, swelling, and irregular heartbeat.